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M9490315.TXT
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1994-09-19
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Document 0315
DOCN M9490315
TI Characteristics of cervical intraepithelial neoplasia in women infected
with the human immunodeficiency virus.
DT 9411
AU Fruchter RG; Maiman M; Sillman FH; Camilien L; Webber CA; Kim DS;
Department of Obstetrics and Gynecology, State University of New; York
Health Science Center at Brooklyn 11203.
SO Am J Obstet Gynecol. 1994 Aug;171(2):531-7. Unique Identifier : AIDSLINE
MED/94337841
AB OBJECTIVE: Our purpose was to compare characteristics of cervical
intraepithelial neoplasia in relation to human immunodeficiency virus
infection among women referred to a public hospital colposcopy clinic
with Papanicolaou smears showing cervical intraepithelial neoplasia.
STUDY DESIGN: An evaluation of cervical intraepithelial neoplasia
severity, lesion size, and vulvovaginal lesions with respect to human
immunodeficiency virus status was performed. RESULTS: (1) Human
immunodeficiency virus prevalence in 482 women with cytologic
characteristics of cervical intraepithelial neoplasia was 13%. (2) In
human immunodeficiency virus-infected patients, Papanicolaou smears were
less adequate for evaluation and correlated less well with histologic
findings than in uninfected patients (p < 0.05). (3) Human
immunodeficiency virus-infected patients (n = 47) had more advanced
cervical intraepithelial neoplasia, larger cervical lesions, and more
associated vulvovaginal lesions than human immunodeficiency
virus-negative patients (n = 161). In human immunodeficiency
virus-positive women, the severity of cervical intraepithelial neoplasia
was not associated with age, whereas in human immunodeficiency
virus-negative women, increasing severity was significantly associated
with increasing age. CONCLUSION: High rates of human immunodeficiency
virus infection in inner-city colposcopy services and high-grade,
extensive cervical lesions in infected women warrant special attention.
DE Adult Cervical Intraepithelial Neoplasia/COMPLICATIONS/*PATHOLOGY
Cervix Neoplasms/COMPLICATIONS/*PATHOLOGY Cross-Sectional Studies
Female Human HIV Infections/*COMPLICATIONS Support, Non-U.S. Gov't
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).